The only known side effect of high-dose pantethine supplementation is increased bowel activity and diarrhea in certain individuals. Human and animal studies have documented the low toxicity and safety of pantethine. Although digestive disturbances have occasionally been reported in the literature, the majority of researchers have commented on the complete freedom from side effects and subjective complaints experienced by individuals taking pantethine. During a one-year clinical trial with pantethine that was conducted in 24 patients with established dyslipidemia, The treatment was well tolerated by all patients with no subjective complaints or detectable side effects. The results were equally good in patients with uncomplicated dyslipidemia and in those with associated diabetes mellitus.[17]